HCID 20094804, 화합물 → 3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-amine
반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=O)[CH2:11][CH2:10][CH:9]([N+:14]([O-])=O)[CH2:8][C:7]=2[CH:17]=1.[H][H]>C(O)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][CH:9]([NH2:14])[CH2:8][C:7]=2[CH:17]=1참가 물질
5
실험 절차
A solution of 2-methoxy-8-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one (0.20 g) in acetic acid (2 ml) was hydrogenated at 4 atm hydrogen atmosphere over 10% palladium on carbon (0.20 g). After removing the catalyst, the pH of the solution was adjusted to 12 with sodium hydroxide solution and the solution was extracted with ethyl acetate. The extract was washed with brine, dried over potassium carbonate, and evaporated in vacuo to give 3-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-amine (153 mg).
후처리
- customAfter removing the catalyst
- extractionthe solution was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over potassium carbonate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-4da40cfde7f443c5bfd2239d4256aa10
- 출처 데이터셋
- uspto-grants-1995_02
- 특허 번호
- US05387710
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