Ammonia → alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

HRID 27408노트

반응식

HRID 27408 반응식
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[NH3:13]>CO>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([NH2:13])=[O:1]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 23342878HCID 23342878, 화합물

생성물 1

HCID 23342879alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamide수율 90%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

10.15 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 100 ml of methanol and the solution is saturated with ammonia, the temperature rising spontaneously to 40° C. The mixture is kept at that temperature for 30 minutes, whereupon it is allowed to return to ambient temperature. The reaction mixture is then evaporated under reduced pressure and the resulting powder is recrystallized from absolute ethanol. 10 g of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained. M.P.: 164°-165° C.; yield: 90% of theory.

후처리

  1. customrising spontaneously to 40° C
  2. customto return to ambient temperature
  3. customThe reaction mixture is then evaporated under reduced pressure
  4. customthe resulting powder is recrystallized from absolute ethanol

출처 및 근거

ORD 기록
ord-3be00ad94a5d4ee49aaca088c2be7f15
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221789

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