Morpholine → HCID 23342866, 화합물

HRID 27410노트

반응식

[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=[O:1]

참가 물질

반응물 2

HCID 8083Morpholine

HCID 23342878HCID 23342878, 화합물

생성물 1

HCID 23342866HCID 23342866, 화합물수율 82%

반응 조건

온도: 110 °C

실험 절차

5.07 g (0,03 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are mixed with 10.45 g (0.12 mol) of morpholine and the reaction mixture is heated at 110° C. for 5 hours. Upon cooling, the product crystallizes. The product is filtered and recrystallized from diethyl ether. 6.3 g (yield: 82% of theory) of 4-[4-hydroxy-2-(2-oxo-1-pyrrolidinyl)butyryl]-morpholine are obtained. M.P.: 105°-106° C.

후처리

temperatureUpon cooling
customthe product crystallizes
filtrationThe product is filtered
customrecrystallized from diethyl ether

출처 및 근거

ORD 기록: ord-998d1067ea0c4e829ca7f57386e40294
출처 데이터셋: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04221789

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