참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Chloroacetamide | HCID 6580 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | methyl N-(2-chloroacetyl)carbamate | HCID 518783 | — |
반응 단계
A suspension of 2-chloroacetamide (122.6 g, 1.31 mol) in 300 ml of 1,2-dichloroethane is cooled to 0° C. and treated with oxalyl chloride (200 g, 1.57 mol). The reaction mixture is heated at reflux for 4 hours. After cooling to 5° C., 68 ml of MeOH is added dropwise while keeping the internal temperature below 15° C. with external cooling. After addition is complete, the product is separated by filtration and washed with CH2Cl2 and Et2O. Recrystallization from CH2Cl2 yields methyl(chloroacetyl)carbamate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04221796 |
|---|
| 출처 데이터셋 | uspto-grants-1980_09 |
|---|
| ORD ID | ord-93e933a150fd4dfdad3e601d64c283ad |
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| 출처 메모 | uspto-grants-1980_09 |
|---|
