Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Chloride → 1-(Phenylmethyl)cycloheptanecarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | Cycloheptanecarbonitrile | HCID 96653 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(Phenylmethyl)cycloheptanecarbonitrile | HCID 18999624 | 55.8% |
반응 단계
Obtained by operating as in example 27b, from 195 mmoles of lithiated diisopropylamine (25.6 g (252.9 mmoles) of diisopropylamine treated with 122 ml (195 mmoles) of n-butyllithium 1.6M in hexane) in 300 ml of dry tetrahydrofuran, 24 g (195 mmoles) of commercial cycloheptanecarbonitrile and 24.6 g (195 mmoles) of benzyl chloride. After distillation, there is obtained 23.2 g (yield=55.8%) of a yellow viscous liquid. b.p.16 =190°-7° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05387709 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-8e8197743c254561b3d8266272a7e85b |
| 출처 메모 | uspto-grants-1995_02 |