2,6-Dimethylquinoline → 4-[2,6-Dimethyl-1quinolinio]butanesulfonate

HRID 274200

반응식

HRID 274200 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:12])[CH:8]=2)[N:3]=1.[CH2:13]1[S:18](=[O:20])(=[O:19])[O:17][CH2:16][CH2:15][CH2:14]1>CC(C)=O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:12])[CH:8]=2)[N+:3]=1[CH2:16][CH2:15][CH2:14][CH2:13][S:18]([O-:20])(=[O:19])=[O:17]

참가 물질

4

반응물 2

HCID 134142,6-DimethylquinolineHCID 154111,4-Butane sultone

생성물 1

HCID 867484494-[2,6-Dimethyl-1quinolinio]butanesulfonate수율 94.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

72.3 g (0.46 mol) of 2,6-dimethylquinoline and 188 g (1.4 mol) of butanesultone were heated at 145° C. for 4 hours with stirring. After being cooled to room temperature, 500 ml of acetone was added to the reaction mixture, which was cooled with ice for 30 minutes for crystallization. The crystals formed were filtered out, washed with acetone and dried to obtain 127.3 g of 4-[2,6-dimethyl-1quinolinio]butanesulfonate. The yield of the product was 94%.

후처리

  1. temperaturewas cooled with ice for 30 minutes for crystallization
  2. customThe crystals formed
  3. filtrationwere filtered out
  4. washwashed with acetone
  5. customdried

출처 및 근거

ORD 기록
ord-264c39146dce4d0d9cbf716bd916f9ed
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389505

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