Methanol → HCID 178484885, 화합물

HRID 274218

반응식

HRID 274218 반응식
S(Cl)([Cl:3])=O.[CH3:5][NH:6][C@H:7]([C:15]([OH:17])=[O:16])[CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:14])[NH2:13].[CH3:18]O>>[ClH:3].[ClH:3].[CH3:18][O:16][C:15](=[O:17])[C@H:7]([CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:13])[NH2:14])[NH:6][CH3:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl Chloride2회HCID 178484884HCID 178484884, 화합물

생성물 1

HCID 178484885HCID 178484885, 화합물

반응 조건

온도
40 °C

실험 절차

6.4 ml of thionyl chloride are added dropwise to a suspension of 15.06 g of N-methylarginine in 50 ml of absolute methanol at -10° C. The mixture is then allowed to come to room temperature, while stirring. Since starting material is still present after a reaction time of 17 hours, a further 9.6 ml of thionyl chloride are added in portions, the mixture is heated at 40° C. for 4 hours, the insoluble material is filtered off with suction and the filtrate is concentrated. The oily residue is dissolved in water, the insoluble material is filtered off and the product is freeze-dried.

후처리

  1. customto come to room temperature
  2. customafter a reaction time of 17 hours
  3. filtrationthe insoluble material is filtered off with suction
  4. concentrationthe filtrate is concentrated
  5. dissolutionThe oily residue is dissolved in water
  6. filtrationthe insoluble material is filtered off
  7. customthe product is freeze-dried

출처 및 근거

ORD 기록
ord-b37a7ab4c7a04dd1a6fb0a747db9b236
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389614

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