Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → 2-(alpha-Cyano-4-chlorobenzylidene)perhydroazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- | HCID 75657 | — |
| 반응물 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 반응물 | Diazabicyclo[5.4.0]undec-5-ene | HCID 22258625 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(alpha-Cyano-4-chlorobenzylidene)perhydroazepine | HCID 70595042 | 67.6% |
반응 단계
Agitate a mixture of 5.0 g of 4-chlorobenzyl cyanide, 5.5 g of caprolactim methyl ether and 0.5 g of diazabicyclo [5.4.0]undec-5-ene under nitrogen for 18 hours at 125°. Cool the thus-obtained reaction mixture to ambient temperature and then rub down the crystallizing residue with 20 ml of methyl alcohol before filtering to obtain 5.5 g of the title compound. Recrystallize this compound from methyl alcohol to obtain a product with a MP of 114° to 117°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221788 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-34ac4d4d324f4803aaa661b56366f157 |
| 출처 메모 | uspto-grants-1980_09 |