Water → 1-Ethyl-2-(4-chlorobenzyl)perhydroazepine

HRID 27429

반응식

HRID 27429 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][CH:7]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:22](Br)[CH3:23].O>C(C(C)=O)C>[CH2:22]([N:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:7]1[CH2:6][C:5]1[CH:14]=[CH:15][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH3:23]

참가 물질

6

반응물 4

HCID 962WaterHCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 39338092-[(4-Chlorophenyl)methyl]azepane

생성물 1

HCID 233428031-Ethyl-2-(4-chlorobenzyl)perhydroazepine

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

Boil together (under agitation) 4 g of 2-(4-chlorobenzyl)perhydroazepine, 2.5 g of anhydrous potassium carbonate and 2.9 g of ethyl bromide under reflux for 26 hours in 30 ml of ethylmethylketone. Cool the thus-produced reaction mixture to ambient temperature. Mix the cooled reaction mixture with water and then extract it with diethyl ether. Dry the resulting organic phase over sodium sulfate, remove the ether and distil the residue to obtain 5.12 g (70% of theory) of the title compound with a BP of 112° at 0.005 mm of Hg.

후처리

  1. temperatureCool
  2. customthe thus-produced reaction mixture to ambient temperature
  3. additionMix
  4. extractionextract it with diethyl ether
  5. dry with materialDry the resulting organic phase over sodium sulfate
  6. customremove the ether
  7. customdistil the residue

출처 및 근거

ORD 기록
ord-61b6237faed14f6ea997de5e8a8ecfe3
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221788

연결된 노트

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