Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylene Glycol → 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylene Glycol | HCID 8172 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 2-(4-Chlorobenzyl)-1-[3-(4-fluorobenzoyl)propyl]perhydroazepine | HCID 23342853 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine | HCID 23342834 | 62.2% |
반응 단계
Heat 0.5 g of the title compound of Example 39 with 1 ml of hydrazine hydrate, 0.5 g of potassium hydroxide and 5 ml of triglycol for 2 hours at 165°. Cool the resulting reaction mixture to ambient temperature. Mix the cooled reaction mixture with water and diethyl ether. Dry the ether phase over sodium sulfate and then concentrate it to obtain 0.3 g of the title compound as a viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221788 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-263ae71c66374e658004a1b702d7a9d6 |
| 출처 메모 | uspto-grants-1980_09 |