2-Aminopyridine → HCID 21459070, 화합물

HRID 274473

반응식

HRID 274473 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>C(O)C>[N:16]1[CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([OH:15])[C:8]([OH:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=2)[N:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=12

참가 물질

4

반응물 2

HCID 104392-AminopyridineHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

생성물 1

HCID 21459070HCID 21459070, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 987.5 mg of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 1.01 g of 2-aminopyridine is melted at 110°. After 30 minutes the melt is treated with 15 ml of ethanol and heated to boiling under reflux for 3 hours. The reaction mixture is then cooled to room temperature and the crystals are removed by filtration under suction. There is obtained 5-(imidazo[1,2-a]pyridin-3-yl)-3-nitropyrocatechol of m.p. 250°14 252° (from N,N-dimethylformamide/methanol).

후처리

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. customthe crystals are removed by filtration under suction

출처 및 근거

ORD 기록
ord-62c7318189ea414bb3cf1e2d12f82e3d
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389653

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