Ammonia → 4-cyano-1H-pyrrole-2-carboxamide

HRID 274732노트

반응식

HRID 274732 반응식
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([C:10]#[N:11])[CH:9]=1)=[O:4].[NH3:14]>CO.O>[C:10]([C:8]1[CH:9]=[C:5]([C:3]([NH2:14])=[O:4])[NH:6][CH:7]=1)#[N:11]

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 127304765-(trichloroacetyl)-1H-pyrrole-3-carbonitrile

생성물 1

HCID 152390864-cyano-1H-pyrrole-2-carboxamide

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 2-trichloroacetylpyrrole-4-carbonitrile (20 g, 84.2 mmol) in methanol is treated with ammonia (51 mL), stirred at room temperature for 30 minutes and diluted with water. The aqueous mixture is filtered to obtain the title product as a white solid (7.0 g, mp 253°-256° C.).

후처리

  1. filtrationThe aqueous mixture is filtered

출처 및 근거

ORD 기록
ord-d13606e42b364f86abc512497f317646
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389669

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