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Potassium Carbonate → Methyl 4-bromo-2-(p-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carboxylate

HRID 274741
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HRID 274741 반응식
[Br:1][C:2]1[C:3]([C:18]([O:20][CH3:21])=[O:19])=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[NH:5][C:6]=1[C:7]([F:10])([F:9])[F:8].C(=O)([O-])[O-].[K+].[K+].[CH2:28]([O:30][CH2:31]Cl)[CH3:29]>O>[Br:1][C:2]1[C:3]([C:18]([O:20][CH3:21])=[O:19])=[C:4]([C:11]2[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=2)[N:5]([CH2:31][O:30][CH2:28][CH3:29])[C:6]=1[C:7]([F:10])([F:9])[F:8]
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참가 물질

5

반응물 3

HCID 11430Potassium Carbonate3회HCID 18523Chloromethyl ethyl ether3회HCID 20093623Methyl 4-bromo-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carboxylate

생성물 1

HCID 20093625Methyl 4-bromo-2-(p-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carboxylate수율 123.4%

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

A mixture of methyl 4-bromo-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carboxylate (9.2 g, 24.1 mmol), potassium carbonate (4.96 g, 36 mmol) and chloromethyl ethyl ether (3.3 mL, 36 mmol) is stirred at room temperature for 21 hours, treated with potassium carbonate (4.9 g) and chloromethyl ethyl ether (3.3 mL), stirred for 1 hour, treated with potassium carbonate (4.9 g) and chloromethyl ethyl ether (3.3 mL) stirred for 3 hours, diluted with water and extracted with diethyl ether. The combined organic extracts are washed with water, dried over anhydrous MgSO4 and concentrated in vacuo to obtain the title product as a brown oil (13.1 g) which is used in the next step without further purification.

후처리

  1. stirringstirred for 1 hour
  2. stirringstirred for 3 hours
  3. extractionextracted with diethyl ether
  4. washThe combined organic extracts are washed with water
  5. dry with materialdried over anhydrous MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cbbf44feb4bc40149f896398098339e4
출처 데이터셋
uspto-grants-1995_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05389669

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