Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propylamine → 8-chloro-2-(N-n-propylamino)tetralin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propylamine | HCID 7852 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 8-Chloro-1,2,3,4-tetrahydronaphthalen-2-one | HCID 4623269 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 8-chloro-2-(N-n-propylamino)tetralin | HCID 14969229 | — |
반응 단계
8-Chloro-2-tetralone (500 mg, 2.78 mMol) in toluene (25 mL) was reacted with propylamine (1.14 mL, 13.9 mMol) and sodium borohydride (500 rag) as described in Example2 to give after purification by flash chromatography (5% methanol in dichloromethane+tr. NH4OH) the title compound as a dark oil (340 mg, 55%). The hydrochloride was formed, and recrystallization (ethanol/diethyl ether) gave a colorless, crystalline solid (m.p.=213°-215° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05389687 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-9d681bdd390848d68b15aa5fbf35ee22 |
| 출처 메모 | uspto-grants-1995_02 |