Dimethylformamide → Methyl 3-benzyloxy-6-ethoxypicolinate

HRID 274881노트

반응식

HRID 274881 반응식
[CH2:1]([O:8][C:9]1[C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:11][C:12]([OH:15])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20](Br)[CH3:21].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[CH2:1]([O:8][C:9]1[C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:11][C:12]([O:15][CH2:20][CH3:21])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 178499129HCID 178499129, 화합물

생성물 1

HCID 20088901Methyl 3-benzyloxy-6-ethoxypicolinate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5.0 g (19 mmol) of methyl 3-benzyloxy-6-hydroxypicolinate, 2.1 g (19 mmol) of ethyl bromide and 2.9 g (21 mmol) of potassium carbonate were added to 100 ml of DMF, and the resultant mixture was reacted at 80° C. for 5 hours. After the reaction, the reaction content was poured into water, and was extracted with ethyl acetate, washed with water, dried and concentrated. The residue thus obtained was purified by column chromatography to obtain an aimed compound.

후처리

  1. customAfter the reaction
  2. extractionwas extracted with ethyl acetate
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated
  6. customThe residue thus obtained
  7. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-6480cc74b20c4b78935446d42d05cad2
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391537

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