Diethylformamide → 2-Amino-6-chloropurine

HRID 274994

반응식

HRID 274994 반응식
C(N(CC)C=O)C.C(N1CCCCC1)=O.C(N(C=[N:22][C:23]1[N:31]=[C:30]2[C:26]([NH:27][CH:28]=[N:29]2)=[C:25]([Cl:32])[N:24]=1)CC)C.N1(C=NC2N=C3C(NC=N3)=C(Cl)N=2)CCCCC1>>[NH2:22][C:23]1[N:31]=[C:30]2[C:26]([NH:27][CH:28]=[N:29]2)=[C:25]([Cl:32])[N:24]=1

참가 물질

5

반응물 4

HCID 12051DiethylformamideHCID 174291-PiperidinecarboxaldehydeHCID 538601682-Diethylaminomethyleneamino-6-chloropurineHCID 539799982-Piperidinomethyleneamino-6-chloropurine

생성물 1

HCID 53603492-Amino-6-chloropurine

실험 절차

The reaction is carried out in the same manner as in Example 2 except that N,N-diethylformamide or N-formylpiperidine is used in the place of N,N-dimethylformamide to yield, respectively, a crystal of 2-diethylaminomethyleneamino-6-chloropurine or 2-piperidinomethyleneamino-6-chloropurine as an intermediate for further synthesis. A further treatment is carried out in the same manner as in Example 2 on these crystals to yield a white crystal of 2-amino-6-chloropurine.

후처리

  1. customto yield

출처 및 근거

ORD 기록
ord-f8efbab678334a79b2529d4e996099eb
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391733

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