Triethyl Citrate → 2-(Oxolan-3-yl)ethan-1-ol

HRID 275058

반응식

HRID 275058 반응식
C(OCC)(=O)C[C:3]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=O)([C:5]([O:7][CH2:8][CH3:9])=O)O.[H][H]>C(O)C>[OH:7][CH2:5][CH2:3][CH:10]1[CH2:15][CH2:14][O:13][CH2:11]1.[OH:13][CH2:11][CH:10]1[CH2:9][CH2:8][O:7][CH2:5][CH2:3]1

참가 물질

5

반응물 2

HCID 6506Triethyl CitrateHCID 178418361HCID 178418361, 화합물

생성물 2

HCID 2773573(Oxan-4-yl)methanol수율 1%HCID 111262252-(Oxolan-3-yl)ethan-1-ol수율 42%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

400 ml of triethyl citrate were hydrogenated at 200° C. and 200 bar together with 1100 ml of ethanol and 60 g of catalyst B (4-mm pellets) until the take-up of hydrogen had ceased. The reaction product was freed from ethanol and distilled under reduced pressure, giving 80 g (42%) of 3-(2'-hydroxyethyl)tetrahydrofuran and 1.8 g (1%) of 4-hydroxymethyltetrahydropyran.

후처리

  1. customwere hydrogenated at 200° C.
  2. distillationdistilled under reduced pressure

출처 및 근거

ORD 기록
ord-86f587d5a01442c69df9ee015b0d18fc
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391771

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