Thionyl Chloride → 2-(3-Trifluoromethylbenzoyl)nicotinoyl chloride

HRID 275260

반응식

HRID 275260 반응식
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](O)=[O:11])=[O:7].S(Cl)([Cl:24])=O>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([Cl:24])=[O:11])=[O:7]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 200788952-(3-Trifluoromethylbenzoyl)nicotinic acid

생성물 1

HCID 200876762-(3-Trifluoromethylbenzoyl)nicotinoyl chloride

실험 절차

A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.8 g) and thionyl chloride (10 ml) was heated at reflux for 3.5 hours. Excess reagent was removed by evaporation to yield 2-(3-trifluoromethylbenzoyl)nicotinoyl chloride as a red-brown gum (2 g) which was used in the next step without further purification.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. customExcess reagent was removed by evaporation

출처 및 근거

ORD 기록
ord-3881d5926da84b78b87d9ae74e1a462f
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05393730

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