Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-[(benzyloxy)carbonyl]-3-(imidazol-1-yl)-L-alanine → (S)-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(imidazol-1-yl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-[(benzyloxy)carbonyl]-3-(imidazol-1-yl)-L-alanine | HCID 10859191 | — |
| 반응물 | (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol | HCID 14930738 | — |
| 생성물 | (S)-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(imidazol-1-yl)propionamide | HCID 53847799 | — |
반응 단계
In an analogous manner to that described above, by the condensation of N-[(benzyloxy)carbonyl]-3-(imidazol-1-yl)-L-alanine and (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol followed by catalytic hydrogenation there was obtained (S)-α-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(imidazol-1-yl)propionamide, MS: 365 (M+H)+, as a colourless foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05393875 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-b0c472b56fac4fe298992e5ae710996e |
| 출처 메모 | uspto-grants-1995_02 |