Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol → rac-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(furan-2-yl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol | HCID 14930738 | — |
| 반응물 | Cbz-3-(2-furyl)-DL-alanine | HCID 20088483 | — |
| 생성물 | rac-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(furan-2-yl)propionamide | HCID 57246147 | — |
반응 단계
In an analogous manner to that described above, by the condensation of (RS)-α-(1-benzyloxyformamido)-3-(furan-2-yl)propionic acid [J. Biol. Chem. 171, 383 (1947)]and (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol followed by catalytic hydrogenation there was obtained rac-α-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(furan-2-yl)propionamide, MS: 365 (M+H)+, as a colourless foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05393875 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-94f259c8e7ee40429f6cefed67bda66f |
| 출처 메모 | uspto-grants-1995_02 |