2-Bromopropane → 2,3-Dimethyl-1-(2-propyl)oxybenzene

HRID 275725노트

반응식

HRID 275725 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH:17]([CH3:19])[CH3:18]>CC(C)=O>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH:17]([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 63582-BromopropaneHCID 106872,3-DimethylphenolHCID 11430Potassium Carbonate

생성물 1

HCID 203083562,3-Dimethyl-1-(2-propyl)oxybenzene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a stirred solution/suspension of 2,3-dimethylphenol (10 g) and potassium carbonate (6.8 g) in acetone (150 ml) at reflux was added 2-bromopropane (46 ml) drop-wise over 30 min. The solution was heated at reflux for 4 days. After cooling, the solvent was evaporated and the residue was dissolved in ether and water. The ether phase was separated and was worked up according to the general procedure. Column chromatography on silica gel (eluent:ethyl acetate/heptane 1:19) afforded pure 2,3-dimethyl-1-(2-propyl)oxybenzene (13.2 g) as a mobile, slightly brown oil which was used without further purification.

후처리

  1. temperatureat reflux
  2. temperatureThe solution was heated
  3. temperatureat reflux for 4 days
  4. temperatureAfter cooling
  5. customthe solvent was evaporated
  6. dissolutionthe residue was dissolved in ether
  7. customThe ether phase was separated

출처 및 근거

ORD 기록
ord-c383f4cca4a8441ba22214930705beff
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352988B2

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