Ethanol → 1,3-Benzoxazol-4-ol

HRID 275798

반응식

HRID 275798 반응식
Cl.[NH2:2][C:3]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][C:4]=1[OH:5].O.[CH2:12](O)C>>[OH:10][C:9]1[C:3]2[N:2]=[CH:12][O:5][C:4]=2[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 962WaterHCID 4592471,3-Benzenediol, 2-amino-, hydrochloride (1:1)

생성물 1

HCID 137206971,3-Benzoxazol-4-ol

실험 절차

2-Aminoresorcinol hydrochloride (2 g) and triethylchloroformate (4.5 ml) were heated to reflux under nitrogen for 3 h. After cooling to room temperature, the reaction mixture was poured into a mixture of water (70 ml) and ethanol (20 ml). The mixture was stirred vigorously for 30 minutes, then left to stand at room temperature overnight. The beige precipitate which formed was collected by filtration, and dried by azeotroping with toluene to give the title compound as a beige solid (1.2 g).

후처리

  1. temperatureto reflux under nitrogen for 3 h
  2. waitleft
  3. waitto stand at room temperature overnight
  4. customThe beige precipitate which formed
  5. filtrationwas collected by filtration
  6. customdried
  7. customby azeotroping with toluene

출처 및 근거

ORD 기록
ord-88646d822d164a579bb5c38570591b6e
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353010B1

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