Water → HCID 135703167, 화합물

HRID 27580노트

반응식

HRID 27580 반응식
[OH:1][CH:2]([CH3:14])[CH2:3][N:4]1[CH:12]=[N:11][C:10]2[C:5]1=[N:6][CH:7]=[N:8][C:9]=2N.N([O-])=[O:16].[Na+].O>C(O)(=O)C>[OH:1][CH:2]([CH3:14])[CH2:3][N:4]1[CH:12]=[N:11][C:10]2[C:9](=[O:16])[NH:8][CH:7]=[N:6][C:5]1=2

참가 물질

5

반응물 3

HCID 962WaterHCID 19429-(2-Hydroxypropyl)adenineHCID 23668193Sodium Nitrite

생성물 1

HCID 135703167HCID 135703167, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

9-(2-Hydroxy-1-propyl)adenine (I, 4.0 g, 20.7 mmol) was suspened in 50% acetic acid (20 ml) and sodium nitrite (4 g, 58 mmol), was slowly added. The mixture was stirred at 25° for 3 hr. The resulting solution was evaporated to dryness and isopropanol added; this operation was repeated once. The solid residue was boiled in isopropanol and filtered. The filtrate was evaporated and crystallized by addition of acetone. Recrystallization was made from iso-propanol/methanol (98:2); a colorless crystalline product was obtained. Yield 3.3 g (82%); M.P. 244°-250°; uv (H2O; pH 5.5), λmax 250 nm.

후처리

  1. customThe resulting solution was evaporated to dryness and isopropanol
  2. additionadded
  3. filtrationfiltered
  4. customThe filtrate was evaporated
  5. customcrystallized by addition of acetone
  6. customRecrystallization
  7. customa colorless crystalline product was obtained

출처 및 근거

ORD 기록
ord-9e325db5ddec4fedac15f39e5a1f0158
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221910

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