N-Methyl-N-methyloxy-2-benzyloxycarbonylamino-5-(3-phenylpropyloxy)benzamide → N-methyl-N-methyloxy-2-amino-5-(3-phenylpropyloxy)benzamide

HRID 275834노트

반응식

HRID 275834 반응식
[CH3:1][N:2]([O:32][CH3:33])[C:3](=[O:31])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:6][C:5]=1[NH:20]C(OCC1C=CC=CC=1)=O>C(OCC)(=O)C.CO.[C].[Pd]>[CH3:1][N:2]([O:32][CH3:33])[C:3](=[O:31])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:6][C:5]=1[NH2:20]

참가 물질

5

반응물 1

HCID 18315368N-Methyl-N-methyloxy-2-benzyloxycarbonylamino-5-(3-phenylpropyloxy)benzamide

생성물 1

HCID 18315339N-methyl-N-methyloxy-2-amino-5-(3-phenylpropyloxy)benzamide

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

N-Methyl-N-methyloxy-2-benzyloxycarbonylamino-5-(3-phenylpropyloxy)benzamide (1.4 g) was dissolved in a mixture of ethyl acetate (10 ml) and methanol (10 ml). To the solution was added 10% palladium-carbon (0.3 g). The mixture was stirred for 24 houks at room temperature under hydrogen atmosphere. The reaction mixture was subjected to filtration. From the filtrate was distilled off the solvent to leave N-methyl-N-methyloxy-2-amino-5-(3-phenylpropyloxy)benzamide as an orange oily product (1.0 g).

후처리

  1. filtrationThe reaction mixture was subjected to filtration
  2. distillationFrom the filtrate was distilled off the solvent

출처 및 근거

ORD 기록
ord-cd93fe0adf0b454bb2c8dffa551ad7ba
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352982B1

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