N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide → Benzamide, 2-amino-N,5-dimethoxy-N-methyl-

HRID 275859노트

반응식

HRID 275859 반응식
[CH3:1][N:2]([O:24][CH3:25])[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[NH:12]C(OCC1C=CC=CC=1)=O>C(OCC)(=O)C.CO.[H][H].[C].[Pd]>[CH3:1][N:2]([O:24][CH3:25])[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[NH2:12]

참가 물질

6

반응물 1

HCID 18315335N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide

생성물 1

HCID 11514001Benzamide, 2-amino-N,5-dimethoxy-N-methyl-수율 104.2%

시약·촉매·용매 4

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

In a mixture of ethyl acetate (8 ml) and methanol (10 ml) was dissolved N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide (0.55 g). To the solution was added 10% palladium-carbon (0.1 g). The mixture was stirred for 40 minutes at ordinary temperature under atmospheric pressure in hydrogen streams. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure. From the concentrate, N-methyl-N-methyloxy 2-amino-5-methyloxy-benzamide (0.35 g) was obtained.

후처리

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3151efb2da3b49d0be0a0571a2d3f433
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352982B1

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