Hydrogen iodide → 9-(1-Hydroxy-2-propyl)-6-iodopurine

HRID 27588

반응식

HRID 27588 반응식
[OH:1][CH2:2][CH:3]([N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2Cl)[CH3:4].[IH:15]>O>[OH:1][CH2:2][CH:3]([N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2[I:15])[CH3:4]

참가 물질

4

반응물 2

HCID 24841Hydrogen iodideHCID 4540192-(6-Chloropurin-9-yl)propan-1-ol

생성물 1

HCID 233429069-(1-Hydroxy-2-propyl)-6-iodopurine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%) mp=193°-194°; uv λmax 276 nm (H2O, pH 5.5).

후처리

  1. filtrationThe precipitate was filtered
  2. customneutralized with anhydrous sodium acetate at 5°
  3. washwashed with a little cold water (3 times)
  4. customRecrystallization from ethanol/H2O
  5. customgave colorless crystals

출처 및 근거

ORD 기록
ord-b007ad1877a8443a983591b1d1b76a55
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221909

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