Ethyl bromoacetate → 1-Piperidineacetic acid, ethyl ester

HRID 275905

반응식

HRID 275905 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C1C=CC=CC=1.C(OCC)C>[N:1]1([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 7748Ethyl bromoacetateHCID 8082Piperidine

생성물 1

HCID 6434661-Piperidineacetic acid, ethyl ester수율 81.8%

시약·촉매·용매 2

HCID 241Benzene용매HCID 3283Diethyl Ether용매

실험 절차

Piperidine(1.87 ml, 18.9 mmol) was added dropwise to a solution of ethyl bromoacetate(1 ml, 9.0 mmol) in benzene(9 ml), stirred for 2 hours at a room temperature, diluted with ethyl ether, washed with saturated NaCl solution. The separated organic layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure to give 1.26 g of the titled compound. (Yield 81.8%)

후처리

  1. washwashed with saturated NaCl solution
  2. dry with materialThe separated organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-48732d13576143678ac59c9e360f283c
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352993B1

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