Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Naphthalenemethanamine → 5,6-Dimethyl-2-(1-naphthylmethyl)amino-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Naphthalenemethanamine | HCID 8355 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315743 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5,6-Dimethyl-2-(1-naphthylmethyl)amino-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride | HCID 18315781 | 87.7% |
반응 단계
After 1-naphthylmethylamine(0.40 ml, 2.7 mmol) and triethylamine (0.38 ml, 2.7 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(0.5 g, 1.8 mmol) in dimethylformamide, 680 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06352993B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-543e57fb366240cf863613b557f49a20 |
| 출처 메모 | uspto-grants-2002_03 |