Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 6-Methoxymethyl-5-methyl-2-(4-fluoro-2-methylphenylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Fluoro-2-methylaniline | HCID 67982 | — |
| 반응물 | 6-Methoxymethyl-5-methyl-2-chloro-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315787 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Methoxymethyl-5-methyl-2-(4-fluoro-2-methylphenylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride | HCID 18315725 | 58.3% |
반응 단계
After 2-methyl-4-fluoroaniline(0.51 g, 4.5 mmol) and triethylamine (0.63 ml, 4.5 mmol) were added to a solution of 6-methoxymethyl-5-methyl-2-chloro-4-(1,2,3,4-tetrahydroisoquinolin-2-yl) pyrimidine(0.9 g, 3 mmol) in dimethylformamide (5 ml), 750 mg of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 25.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06352993B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-4dd83efb903749b8b241e0ad758a2b9e |
| 출처 메모 | uspto-grants-2002_03 |