Triethylamine → 5,6-Dimethyl-2-chloro-4-(5-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

HRID 275944

반응식

HRID 275944 반응식
[CH3:1][CH:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][NH:3]1.C(N(CC)CC)C.[CH3:21][C:22]1[C:23](Cl)=[N:24][C:25]([Cl:29])=[N:26][C:27]=1[CH3:28]>CN(C)C=O>[CH3:21][C:22]1[C:23]([N:3]2[CH2:4][CH2:5][C:6]3[C:11](=[CH:10][CH:9]=[CH:8][C:7]=3[O:12][CH3:13])[CH:2]2[CH3:1])=[N:24][C:25]([Cl:29])=[N:26][C:27]=1[CH3:28]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2415532,4-Dichloro-5,6-dimethylpyrimidineHCID 183156461-Methyl-5-methoxy-1,2,3,4-tetrahydro-isoquinoline

생성물 1

HCID 183158305,6-Dimethyl-2-chloro-4-(5-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine수율 70.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

After 1-methyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline(0.9 g, 5.1 mmol) and triethylamine(0.7 ml, 5.1 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimidine(0.8 g, 4.64 mmol) in dimethylformamide, 1.0 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35. (Yield: 70.3%)

출처 및 근거

ORD 기록
ord-0543e04e7ee04fb8af785085f92c62f4
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352993B1

연결된 노트

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