Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 5,6Dimethyl-2-(4-fluorophenylamino)-4-{1-methyl-6-(1-piperidineacetoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}pyrimidine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 2-(Piperidin-1-yl)acetic acid hydrochloride | HCID 201096 | — |
| 반응물 | 5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315832 | — |
| 생성물 | 5,6Dimethyl-2-(4-fluorophenylamino)-4-{1-methyl-6-(1-piperidineacetoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}pyrimidine dihydrochloride | HCID 69948315 | — |
반응 단계
The same procudures as in Example 167 were repeated using 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(50 mg, 0.132 mmol), 1-hydroxybenzotriazole(26.8 mg, 0.198 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(32.9 mg, 0.171 mmol), 1-piperidineacetic acid hydrochloride (28.5 mg, 0.158 mmol), and triethylamine(46 μl, 0.330 mmol) to afford the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06352993B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-85a841f75a7342ac9f763c474f38970d |
| 출처 메모 | uspto-grants-2002_03 |