Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-(2-Chlorobenzyl)-6-ethoxycarbonyl-2-methylbenzimidazole | HCID 18680839 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole | HCID 18680817 | 99.7% |
반응 단계
To 60.0 g of 1-(2-chlorobenzyl)-6-ethoxycarbonyl-2 -methylbenzimidazole were added 240 g of a 10% sodium hydroxide aqueous solution and 200 ml of ethanol, and the mixture was heat-refluxed for 2 hours. The reaction solution was cooled, and was then adjusted to a pH of 6 with 10% hydrochloric acid. The crystals precipitated were separated through filtration, and were dried to give 54.7 g of 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (121).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06352985B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-ae6e4656e61941229b14dc8ec8d70536 |
| 출처 메모 | uspto-grants-2002_03 |