Benzenesulfonamide → 6-Benzenesulfonylcarbamoyl-1-(2-chlorobenzyl)-2-methylbenzimidazole

HRID 276042

반응식

HRID 276042 반응식
[C:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:11]=[C:10]([CH3:12])[N:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:8]=2[CH:21]=1)([OH:3])=O.[C:22]1([S:28]([NH2:31])(=[O:30])=[O:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C1(C2CCCCCCCCCC=2)CCCCCCCCNN=1>CN(C)C=O>[C:22]1([S:28]([NH:31][C:1]([C:4]2[CH:5]=[CH:6][C:7]3[N:11]=[C:10]([CH3:12])[N:9]([CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[Cl:20])[C:8]=3[CH:21]=2)=[O:3])(=[O:30])=[O:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 7370BenzenesulfonamideHCID 186808176-Carboxy-1-(2-Chlorobenzyl)-2-MethylbenzimidazoleHCID 536302743-(Cycloundecen-1-yl)-1,2-diazacycloundec-2-ene

생성물 1

HCID 179386716-Benzenesulfonylcarbamoyl-1-(2-chlorobenzyl)-2-methylbenzimidazole수율 58.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N,N′-carbonyldiimidazole (45.8 g) was added at a time to a solution of 45.0 g of 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole in 950 ml of N,N-dimethylformamide, and the mixture was stirred at room temperature for 1 hour. Subsequently, 47.1 g of benzenesulfonamide and 35.0 g of diazabicycloundecene were added thereto, and the mixture was stirred at 100° C. for 70 hours. The reaction solution was cooled, and the solvent was distilled off under reduced pressure. To the residue were added 300 ml of water and 200 ml of methanol. Further, 60.7 g of 35% hydrochloric acid were added thereto to adjust the solution to a pH of 5.5. The crystals precipitated were separated through filtration, washed with 200 ml of a mixed solution of methanol and water (at a ratio of 1:1), and dried to obtain 38.4 g of 6-benzenesulfonylcarbamoyl-1-(2-chlorobenzyl)-2-methylbenzimidazole. Water was added to the filtrate. The crystals precipitated were separated through filtration, washed with water, and dried. The amount of the crystals was 13.3 g. The crystals were combined, and were dissolved by being heated with the addition of 3300 ml of acetone and 900 ml of water. From this solution, 200 ml of the solvent were distilled off while being heated, and the residue was cooled. The crystals precipitated were separated through filtration, and were dried to give 33.8 g of 6-benzenesulfonylcarbamoyl-1-(2-chlorobenzyl)-2-methylbenzimidazole (163).

후처리

  1. stirringthe mixture was stirred at 100° C. for 70 hours
  2. temperatureThe reaction solution was cooled
  3. distillationthe solvent was distilled off under reduced pressure
  4. additionTo the residue were added 300 ml of water and 200 ml of methanol
  5. additionFurther, 60.7 g of 35% hydrochloric acid were added
  6. customThe crystals precipitated
  7. customwere separated through filtration
  8. washwashed with 200 ml of a mixed solution of methanol and water (at a ratio of 1:1), and
  9. customdried

출처 및 근거

ORD 기록
ord-debef6073b18444ebbe20ff05599ae1c
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352985B1

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