Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → 4,5-dihydro-1-(3-mercapto-1-oxopropyl)-4-methoxy-1H-pyrrole-2-carboxylic acid
반응식
C([O:5][C:6](=[O:14])[C@@H:7]1[CH2:11][CH:10]([O:12][CH3:13])[CH2:9][NH:8]1)(C)(C)C.COC1CN[C@H](C(O)=O)C1.N1CCC[C@H]1C(O)=O.C(OC(=O)[C@@H]1CCCN1)(C)(C)C.C([S:48][CH2:49][CH2:50][C:51](Cl)=[O:52])(=O)C.C(SCC(C)C(Cl)=O)(=O)C>>[SH:48][CH2:49][CH2:50][C:51]([N:8]1[CH2:9][CH:10]([O:12][CH3:13])[CH:11]=[C:7]1[C:6]([OH:5])=[O:14])=[O:52]참가 물질
7
반응물 6
생성물 1
실험 절차
By substituting 4-methoxy-L-proline tert-butyl ester [prepared from 4-methoxy-L-proline by the procedure described in J. Am. Chem. Soc., 82, 3359 (1960) for L-proline] for the L-proline tert-butyl ester and 3-acetylthiopropanoyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1, and then submitting the product to the procedure of Example 2, 4,5-dihydro-1-(3-mercapto-1-oxopropyl)-4-methoxy-1H-pyrrole-2-carboxylic acid is obtained.
출처 및 근거
- ORD 기록
- ord-1a45026a3a0b4759a631b4eaeb0394b6
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04221912
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