Cyclopropanemethanamine, N-propyl- → N-Cyclopropylmethyl-N-propyl-4-(2,4,6-trimethylphenyl)-1-phthalazinamine

HRID 276106

반응식

HRID 276106 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[C:10]1(Cl)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[N:12][NH:11]1.[CH2:21]([NH:24][CH2:25][CH:26]1[CH2:28][CH2:27]1)[CH2:22][CH3:23]>C1(C)C=CC=CC=1>[CH:26]1([CH2:25][N:24]([CH2:21][CH2:22][CH3:23])[C:13]2[C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:10]([C:3]3[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[CH:5][C:4]=3[CH3:9])=[N:11][N:12]=2)[CH2:28][CH2:27]1

참가 물질

4

반응물 2

HCID 117787Cyclopropanemethanamine, N-propyl-HCID 184326574-(2,4,6-Trimethylphenyl)-4-chloro-phthalazine

생성물 1

HCID 9950734N-Cyclopropylmethyl-N-propyl-4-(2,4,6-trimethylphenyl)-1-phthalazinamine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of the product of step C (100 mg), N-propyl-N-cyclopropylmethylamine (0.5 mL) and in 1 mL of toluene was heated at 100° C. overnight. The mixture was cooled and concentrated. The residue was purified through silica gel column chromatography to give 40 mg of the title compound as an oil. 1H NMR (CDCI3): δ0.08 (q, 2H), 0.50 (q 2H), 0.95 (t, 3H), 1.20 (m, 1H), 1.76 9 m, 2H), 1.92 (s, 6H), 2.36)s, 3H), 3.45 (d, 2H), 3.68 (m, 2H), 6.90 (s, 2H), 7.36 (d, 1H), 7.64 (t, 1H), 7.74 (t, 1H), 8.19 (d, 1H)ppm.

후처리

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated
  3. customThe residue was purified through silica gel column chromatography

출처 및 근거

ORD 기록
ord-ae6eeea1cde04040a59aed797b372c64
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353103B1

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