HCID 22341850, 화합물 → HCID 22182264, 화합물
반응식
[CH3:1][C:2]1([CH3:13])[CH2:7][C:6](=[O:8])[CH2:5][C:4]([CH2:11][CH3:12])([CH2:9][CH3:10])[NH:3]1>CO>[CH3:13][C:2]1([CH3:1])[CH2:7][CH:6]([OH:8])[CH2:5][C:4]([CH2:9][CH3:10])([CH2:11][CH3:12])[NH:3]1참가 물질
3
실험 절차
To a solution of 15.8 g (0.086 mol) 2,2-dimethyl-6,6-diethyl-4-oxopiperidine in 50 ml methanol 2.2 g (0.06 M) sodium borohydride are added in portions. The temperature is kept below 30° C. After stirring over night methanol is removed under vacuum and the residue is diluted with 20 ml 2N—NaOH. The solution is extracted with ethylacetate. The combined extracts are washed with saturated NaCl solution, dried over MgSO4 and dried under vacuum at 60° C./50 mbar until a constant weight is achieved. 15.8 g (99%) 2,2-dimethyl-6,6-diethyl-4-hydroxypiperidine are obtained as yellowish oil.
후처리
- customis kept below 30° C
- customis removed under vacuum
- additionthe residue is diluted with 20 ml 2N—NaOH
- extractionThe solution is extracted with ethylacetate
- washThe combined extracts are washed with saturated NaCl solution
- dry with materialdried over MgSO4
- customdried under vacuum at 60° C./50 mbar until a constant weight
출처 및 근거
- ORD 기록
- ord-95b825b6228445f5a3e9eecdb27d2695
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06353107B1
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