4-Toluenesulfonyl chloride → (1-((4-Methylphenyl)sulfonyl)-1H-imidazol-5-yl)methanol

HRID 27613

반응식

HRID 27613 반응식
C(=O)(O)[O-].[Na+].Cl.[NH:7]1[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[CH:8]1.[S:14](Cl)([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15]>O.C(OCC)(=O)C>[S:14]([N:7]1[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[CH:8]1)([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15]

참가 물질

6

반응물 3

HCID 73974-Toluenesulfonyl chlorideHCID 122926Imidazol-4-ylmethanol hydrochlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 382151(1-((4-Methylphenyl)sulfonyl)-1H-imidazol-5-yl)methanol

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To an ice cold solution of 0.08 mole of sodium bicarbonate in 40 ml of water is added 0.02 mole of imidazol-5-ylmethanol hydrochloride followed by a solution of 0.025 mole of tosylchloride in 30 ml of ethyl acetate. The reaction mixture is stirred at room temperature for 5 hours. The organic phase is separated, washed with sodium bicarbonate, and dried over magnesium sulfate and concentrated under reduced pressure. The residue is crystallized from ethyl acetate to afford 1-tosylimidazol-5-ylmethanol.

후처리

  1. customThe organic phase is separated
  2. washwashed with sodium bicarbonate
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-0234d9088d344fc98eb9e0fe5af5aad6
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221914

연결된 노트

불러오는 중…