Benzaldehyde → Heptanophenone

HRID 276163

반응식

HRID 276163 반응식
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C(C)=CC=CN=1.N[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(O)(=O)C1C=CC=CC=1.C=CCCCC>C1(C)C=CC=CC=1>[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:8])[CH2:22][CH2:23][CH2:18][CH2:19][CH2:20][CH3:21]

참가 물질

7

반응물 5

HCID 240BenzaldehydeHCID 243Benzoic AcidHCID 6115AnilineHCID 115971-HexeneHCID 153472-Amino-3-methylpyridine

생성물 1

HCID 74282Heptanophenone

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
130 °C

실험 절차

Under the same reaction procedure and conditions as in Example 1 (benzaldehyde 0.5 mmol, 2-amino-3-picoline 0.1 mmol, aniline 0.3 mmol, bezoic acid 0.03 mmol), 1-hexene and toluene at various amounts as shown in the following table 8, were added to each 500 ml pressure reactor. The mixture was stirred at normal temperature for 2-3 minutes and then combined with Rh(PPh3)3Cl 0.01 mmol. While the reactor was stopped with a stopper, the reactants were heated at 130 ° C. for 1 hour with stirring. After completion of the reaction, gas chromatography was conducted to determine the yields of heptanophenone, products according to 1-hexene and toluene of various amounts. The results are given in Table 8, below.

후처리

  1. additionwere added to each 500 ml pressure reactor
  2. stirringwith stirring
  3. customAfter completion of the reaction, gas chromatography

출처 및 근거

ORD 기록
ord-e56a499df361484da4911e91fe4f2d06
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353139B1

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