benzyl N-[1-(hydroxymethyl)cyclohexyl]carbamate → (1-Aminocyclohexyl)methanol
반응식
C(OC([NH:11][C:12]1([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C:12]1([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1참가 물질
4
실험 절차
A slurry of 1-(benzyloxycarbonylamino)-1-(hydroxymethyl)cyclohexane (4.0 g, 15 mmol) and 10% Pd/C (0.40 g) in MeOH (75 ml) was stirred under H2 (1 atm.) for 1 h, then treated with Celite®. The resulting mixture was filtered and concentrated under reduced pressure to give 1-amino-1-(hydroxymethyl)cyclohexane.
후처리
- additiontreated with Celite®
- filtrationThe resulting mixture was filtered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-b96e79cfef164e66b54433207daa4f14
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06353006B1
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