Isobutylamine → 1-(Isobutylamino)-3-phenylpropan-2-ol

HRID 276263

반응식

HRID 276263 반응식
[O:1]1[CH2:10][CH:2]1[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:11]([NH2:15])[CH:12]([CH3:14])[CH3:13]>O>[C:4]1([CH2:3][CH:2]([OH:1])[CH2:10][NH:15][CH2:11][CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 6558IsobutylamineHCID 948262-(Phenylmethyl)oxirane

생성물 1

HCID 4120961-(Isobutylamino)-3-phenylpropan-2-ol수율 42.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
110 °C

실험 절차

2,3-Epoxypropyl benzene (10 g, 74.5 mmol) and isobutylamine (5.4 g, 74.5 mmol) were mixed then treated with water (2 mL). The mixture was stirred overnight at 110° C., then distilled to yield N-(3-phenyl-2-hydroxypropyl)N-isobutylamine (6.5 g): bp 115-117° C. (1 mmHg).

후처리

  1. distillationdistilled

출처 및 근거

ORD 기록
ord-38e71653d71648c093523f85378accd1
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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