참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 1-(Cyclohexylamino)-1-(hydroxymethyl)cyclopentane | HCID 18316142 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt | HCID 69992905 | 195.8% |
반응 단계
A 4M HCl solution (p-dioxane, 40 mL) containing 1-(cyclohexylamino)-1-(hydroxymethyl)cyclopentane (Method B4a; 1.9 g, 9.6 mmol) and SOCl2 (0.84 mL, 11.5 mmol) was heated to 70° C. for 18 h. The resulting mixture was cooled to room temp. and concentrated under reduced pressure to yield crude 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt (2.84 g), which was used in the next step without firer purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06353006B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_03 |
|---|
| ORD ID | ord-2c95e3be24164d069c9b63100bdf0900 |
|---|
| 출처 메모 | uspto-grants-2002_03 |
|---|
