Thionyl Chloride → 1-Cyclohexyl-2-(2-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane
반응식
[CH:1]1([NH:7][C:8]2([CH2:13]O)[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)Cl.[CH3:19][C:20]1[CH:25]=[C:24]([N+:26]([O-:28])=[O:27])[CH:23]=[CH:22][C:21]=1[N:29]=[C:30]=[S:31]>>[CH:1]1([N:7]2[C:8]3([CH2:12][CH2:11][CH2:10][CH2:9]3)[CH2:13][S:31][C:30]2=[N:29][C:21]2[CH:22]=[CH:23][C:24]([N+:26]([O-:28])=[O:27])=[CH:25][C:20]=2[CH3:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
4
실험 절차
1-(Cyclohexylamino)-1-(hydroxymethyl)cyclopentane (Method B4a; 1.89 g, 9.59 mmol) was reacted with SOCl2 followed by 2-methyl-4-nitrophenyl isothiocyanate in a manner analogous to Method C2a to yield 1-cyclohexyl-2-(2-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane (0.44 g, 17%): CI-MS m/z 374 ((M+H)+).