1-Chloro-3-isothiocyanato-2-methylbenzene → 2-(3-Chloro-2-methylphenylimino)-3-(cyclopentylmethyl)-1,3-thiazolidine

HRID 276384

반응식

HRID 276384 반응식
[Cl-].[CH:2]1([CH2:7][NH2+:8][CH2:9][CH2:10]Cl)[CH2:6][CH2:5][CH2:4][CH2:3]1.[Cl:12][C:13]1[C:14]([CH3:22])=[C:15]([N:19]=[C:20]=[S:21])[CH:16]=[CH:17][CH:18]=1>>[Cl:12][C:13]1[C:14]([CH3:22])=[C:15]([N:19]=[C:20]2[N:8]([CH2:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6]3)[CH2:9][CH2:10][S:21]2)[CH:16]=[CH:17][CH:18]=1

참가 물질

3

반응물 2

HCID 1405041-Chloro-3-isothiocyanato-2-methylbenzeneHCID 18316280N-cyclopentylmethyl-N-(2-chloroethyl)ammonium chloride

생성물 1

HCID 183162392-(3-Chloro-2-methylphenylimino)-3-(cyclopentylmethyl)-1,3-thiazolidine

실험 절차

2-Hydroxyethylamine was reacted with cyclopentylmethyl bromide according to Method B2a to give N-cyclopentylmethyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cyclopentylmethyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 3-chloro-2-methylphenyl isothiocyanate to give 2-(3-chloro-2-methylphenylimino)-3-(cyclopentylmethyl)-1,3-thiazolidine.

출처 및 근거

ORD 기록
ord-df0ac5b64f9d4de38cad3382da8173a3
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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