Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → (4S)-2-(2-methyl-4-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | Isobutylaminehydrochloride | HCID 21133 | — |
| 반응물 | (+)-L-Leucine methyl ester | HCID 65105 | — |
| 반응물 | L-Leucinol | HCID 111307 | — |
| 반응물 | 2-Methyl-4-nitrophenyl isothiocyanate | HCID 145621 | — |
| 반응물 | (2S)-4-methyl-2-(isobutylamino)pentanol | HCID 22951222 | — |
| 생성물 | (4S)-2-(2-methyl-4-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine | HCID 10291492 | — |
반응 단계
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (2S)-4-methyl-2-(isobutylamino)pentan-1-ol as described in Method B4c. The resulting 2-hydroxyethylamine was converted to N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride according to Method B7c. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride to Method C1b to afford (4S)-2-(2-methyl-4-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06353006B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-70e26867b02c4090acfc1fa3aedbbcdd |
| 출처 메모 | uspto-grants-2002_03 |