4-Nitro-1-naphthylamine → HCID 178445847, 화합물

HRID 276470

반응식

HRID 276470 반응식
OC[C@@H](N)CC(C)C.COC(=O)[C@H](CC(C)C)N.[N+:19]([C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]([NH2:32])=[CH:24][CH:23]=1)([O-:21])=[O:20].[N+]([C:36]1[C:45]2[C:40](=CC=C[CH:44]=2)[C:39]([N:46]=[C:47]=[S:48])=[CH:38]C=1)([O-])=O>>[N+:19]([C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]([N:32]=[C:47]2[NH:46][C@@H:39]([CH2:40][CH:45]([CH3:36])[CH3:44])[CH2:38][S:48]2)=[CH:24][CH:23]=1)([O-:21])=[O:20]

참가 물질

5

반응물 4

HCID 130574-Nitro-1-naphthylamineHCID 65105(+)-L-Leucine methyl esterHCID 111307L-Leucinol2회HCID 183160794-Nitro-1-naphthyl isothiocyanate2회

생성물 1

HCID 178445847HCID 178445847, 화합물

실험 절차

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. 4-Nitro-1-naphthylamine was converted to 4-nitro-1-naphthyl isothiocyanate according to Method A2b. 4-Nitro-1-naphthyl isothiocyanate was reacted with (1S)-1-(hydroxymethyl)-3-methylbutylamine to Method C2a to give (4S)-2-(4-nitro-1-naphthylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-nitro-1-naphthylimino)-3,4-diisobutyl-1,3-thiazolidine.

출처 및 근거

ORD 기록
ord-95adf840d7bd42c58444000ce7f94ab8
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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