Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → (4S)-2-(4-methoxycarbonyl-2-methylphenylimino)-4-(2-butyl)-1,3-thiazolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | L-Isoleucine, methyl ester | HCID 75735 | — |
| 반응물 | (2S)-2-amino-3-methylpentan-1-ol | HCID 11789185 | — |
| 반응물 | Methyl 4-isothiocyanato-3-methylbenzoate | HCID 18316033 | — |
| 생성물 | (4S)-2-(4-methoxycarbonyl-2-methylphenylimino)-4-(2-butyl)-1,3-thiazolidine | HCID 178445846 | — |
반응 단계
(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Methoxycarbonyl-2-methylphenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride to Method C1a to give (4S)-2-(4-methoxycarbonyl-2-methylphenylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(4-methoxycarbonyl-2-methylphenylimino)-4-(2-butyl)-3-isobutyl-1,3-thiazolidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06353006B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-607c1d04083b4aedbf991328573826fc |
| 출처 메모 | uspto-grants-2002_03 |