Ethanolamine → HCID 178445841, 화합물

HRID 276481

반응식

HRID 276481 반응식
O[CH2:2][C@@H:3]([NH2:8])[CH:4]([CH3:7])[CH2:5][CH3:6].COC(=O)[C@H]([C@H](CC)C)N.OCCN.ClC1C=CC(N)=CC=1C(F)(F)F.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([N:42]=[C:43]=[S:44])=[CH:38][C:37]=1[C:45]([F:48])([F:47])[F:46]>>[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([N:42]=[C:43]2[NH:8][C@@H:3]([CH:4]([CH2:5][CH3:6])[CH3:7])[CH2:2][S:44]2)=[CH:38][C:37]=1[C:45]([F:46])([F:47])[F:48]

참가 물질

6

반응물 5

HCID 700EthanolamineHCID 675744-Chloro-3-(trifluoromethyl)anilineHCID 75735L-Isoleucine, methyl esterHCID 5200261-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene2회HCID 11789185(2S)-2-amino-3-methylpentan-1-ol

생성물 1

HCID 178445841HCID 178445841, 화합물

실험 절차

(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Chloro-3-(trifluoromethyl)aniline was converted to 4-chloro-3-(trifluoromethyl)phenyl isothiocyanate according to Method A2a, Step 3 4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride according to Method C1a to give (4S)-2-(4-chloro-3-(trifluoromethyl)phenylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(4-chloro-3-(trifluoromethyl)phenylimino)-4-(2-butyl)-3-isobutyl-1,3-thiazolidine.

출처 및 근거

ORD 기록
ord-5fa6ed4278f44503a2578b2b396b72e8
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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