Ethanolamine → HCID 178445848, 화합물

HRID 276485

반응식

HRID 276485 반응식
OC[C@@H](N)C(C)CC.COC(=O)[C@H]([C@H](CC)C)N.OCCN.[N+:23]([C:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:29]([NH2:36])=[CH:28][CH:27]=1)([O-:25])=[O:24].[N+](C1[C:49]2[C:44](=[CH:45]C=C[CH:48]=2)[C:43]([N:50]=[C:51]=[S:52])=[CH:42]C=1)([O-])=O>>[N+:23]([C:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:29]([N:36]=[C:51]2[NH:50][C@@H:43]([CH:44]([CH2:49][CH3:48])[CH3:45])[CH2:42][S:52]2)=[CH:28][CH:27]=1)([O-:25])=[O:24]

참가 물질

6

반응물 5

HCID 700EthanolamineHCID 130574-Nitro-1-naphthylamineHCID 75735L-Isoleucine, methyl esterHCID 11789185(2S)-2-amino-3-methylpentan-1-olHCID 18316079HCID 18316079, 화합물2회

생성물 1

HCID 178445848HCID 178445848, 화합물

실험 절차

(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Nitro-1-naphthylamine was converted to 4-nitro-1-naphthyl isothiocyanate according to Method A2b. 4-Nitro-1-naphthyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride to Method C1a to give (4S)-2-(4-nitro-1-naphthylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-nitro-1-naphthylimino)-4-butyl-3-isobutyl-1,3-thiazolidine.

출처 및 근거

ORD 기록
ord-44b8242f55f74fb0b14e66dcd94b14b7
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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