참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | L-Isoleucine, methyl ester | HCID 75735 | — |
| 반응물 | (2S)-2-amino-3-methylpentan-1-ol | HCID 11789185 | — |
| 반응물 | 4-Cyano-2-methylphenyl isothiocyanate | HCID 18316299 | — |
| 생성물 | 4-Amino-3-methylbenzonitrile | HCID 7010316 | — |
| 생성물 | HCID 178445843 | HCID 178445843 | — |
반응 단계
(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Cyano-2-methylaniline was synthesized as described in Method A1a. The aniline was converted to 4-cyano-2-methylphenyl isothiocyanate as described in Method A2a, Step 3. 4-Cyano-2-methylphenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride to Method C1a to give (4S)-2-(4-cyano-2-methylphenylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-cyano-2-methylphenylimino)-4-butyl-3-isobutyl-1,3-thiazolidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06353006B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_03 |
|---|
| ORD ID | ord-f2ed8f833b1442dc8ea4d3b91a740237 |
|---|
| 출처 메모 | uspto-grants-2002_03 |
|---|
