Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 276499생성일: 2026년 10월 25일
Ethanolamine → N-((1S)-1-(4-chlorophenylmethyl)-2-chloroethyl)-N-isobutylammonium chloride
https://huagongshe.com/reaction/276499
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 1,3-Oxazolidine | HCID 536683 | — |
| 반응물 | (S)-2-Amino-3-(4-chlorophenyl)propan-1-OL | HCID 719509 | — |
| 반응물 | (4S)-2-isopropyl-4-(4-chlorophenylmethyl)-1,3-oxazolidine | HCID 57189183 | — |
| 반응물 | N-((1S)-1-(4-chlorophenylmethyl)-2-hydroxyethyl)-N-isobutylamine | HCID 69993392 | — |
| 생성물 | N-((1S)-1-(4-chlorophenylmethyl)-2-chloroethyl)-N-isobutylammonium chloride | HCID 22951241 | — |
반응 단계
(1S)-1-(4-Chlorophenylmethyl)-2-hydroxyethylamine was made from (L)-4-chlorophenylalanine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (4S)-2-isopropyl-4-(4-chlorophenylmethyl)-1,3-oxazolidine according to Method B4c, Step 1. The oxazolidine was reduced to N-((1S)-1-(4-chlorophenylmethyl)-2-hydroxyethyl)-N-isobutylamine according to Method B4c, Step 2. The resulting 2-Hydroxyethylamine was treated with SOCl2 according to Method B7c to give N-((1S)-1-(4-chlorophenylmethyl)-2-chloroethyl)-N-isobutylammonium chloride. 2-Ethyl-4-cyanophenyl isothiocyanate was reacted with N-((1S)-1-(4-chlorophenylmethyl)-2-chloroethyl)-N isobutylammonium chloride according to Method C1b to give (4S)-2-(2-ethyl-4-cyanophenylimino)-4-(4-chlorophenylmethyl)-3-isobutyl-1,3-thiazolidine HCl salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06353006B1 |
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| 출처 데이터셋 | uspto-grants-2002_03 |
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| ORD ID | ord-dc036e81bb9448f2b749aafb9919532d |
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| 출처 메모 | uspto-grants-2002_03 |
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